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Chronic blistering skin disease

Professional Name Pemphigus vulgaris

Summary

Pemphigus vulgaris describes blisters appearing on the mucous membranes or the skin. It is caused by an abnormal autoimmune reaction. Pemphigus vulgaris can be dangerous. Therefore, it is recommended to visit a doctor if there are suspicious symptoms.

Description

Pemphigus vulgaris is a condition where there are blisters on the mucous membranes or the skin. It is mainly caused by an abnormal autoimmune reaction. In this autoimmune reaction the autoimmune system will attack its own proteins and lead to blisters. The blisters often start to appear on the oral mucous membrane, however, it can happen to either mucous membranes or the skin.

Occurrence + Symptoms

The cause of pemphigus vulgaris is an abnormal autoimmune reaction, but the trigger is unknown. The misdirected autoimmune system may attack its own proteins with antibodies. In consequence of this the attacked skin layer may be separated and become inflamed. During the process of inflammation, fluid may start to accumulate under the skin or mucous membranes and then blisters may develop. The blisters are painful and tend to burst easily. There are three different types of pemphigus vulgaris: one affecting the mucosa, one affecting the skin and one affecting both mucosa and skin. The disease proceeds in episodes and reappears for long time (chronic). Besides, UV radiation, mechanical irritation (scratching) and certain kinds of medication such as penicillamine and ACE inhibitors can trigger the blisters.

Consequences + Treatment

The treatment of pemphigus vulgaris will depend on the cause and severity. If it is triggered by a specific medication, then its intake should be stopped. Pemphigus vulgaris can be treated by medication that inhibits the autoimmune system. For example, medication such as immunosuppressive drugs and corticosteroids are often used. These medications often need to be taken over a long period of time.

Possible symptoms of the disease:

formation of blisters (vesicles) on a place of the skin
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